I just started up my Macintosh computer for the first time and noticed that there is a file in the Trash named System Resources. Is it safe to delete this file?

Yes, if you find a file named System Resources in your Trash you can safely empty the Trash.

This can happen when the system starts up for the first time and detects a difference between the version of the existing System Resources file and the version of the PowerPC Enabler. If the System Resources file is older, it is moved to the Trash and a newer version is created dynamically.